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Pancreas Transplantation

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Pancreas Transplantation

As the name suggests, Pancreas Transplantation in Pune is an organ transplant procedure to implant a healthy pancreas in to an individual usually with diabetes. Pancreas transplant is needed, if the pancreas in an individual is unable to produce insulin which is vital for digestion. In a pancreas transplant surgery, the recipient’s native pancreas is left in place, and the pancreas from the donor attached at a different location. This is done to avoid life-threatening diabetes if the recipient’s body rejects the donated pancreas.

Pancreas transplant is not as common as other transplants such as kidney, liver usually performed on individuals with insulin dependent diabetes. The healthy pancreas is received from an individual who has just died or partial pancreas from a living donor. Pancreas transplant is usually performed on patients with insulin dependent diabetes that can develop in to severe complications. Patients who have the most deadly form of pancreatic cancer “pancreatic adenoma” which is usually malignant are not suitable for pancreatic transplant. This is because the condition has high chances of mortality which comes back in some time.

The pancreas in the human body is a tadpole shaped organ, it is about 10-15 cm long located in the top half of the abdomen. Pancreas performs two vital functions, produce juices needed by the body to digest fats and proteins and secondly, produce the insulin hormone for the body to break down glucose in to energy. In the condition of Type 1 diabetes, the pancreas does not produce insulin as the pancreas producing cells known as islets are destroyed by the body’s immune system. Many times the condition can be controlled using regular injections of insulin, but in some cases though small it leads to severe complications.

Some of the complications related to Type 1 diabetes are End Stage Kidney disease, diabetic retinopathy, diabetic neuropathy and arterial diseases. All of these conditions are related to insulin imbalance in some form to that particular organ. Pancreas transplant is carried out either alone or simultaneously with kidney transplant or sometimes after kidney transplant to reduce progression of complications of diabetes.

Pancreas transplant is of four types; Pancreas transplant alone which is performed for individuals with Type 1 diabetes who usually have frequent, severe hypoglycemia but adequate kidney function; simultaneous kidney-pancreas transplant (SPK) when both the organs are transplanted from the same deceased person; pancreas after kidney transplant (PAK) when a deceased donor pancreas transplant is performed after a previous kidney transplant; simultaneous deceased donor pancreas and live donor kidney are performed which has the benefit of low rate of delayed graft function also improves outcome considerably. The standard practice is to preserve until implant, in which the donor’s blood in the pancreatic tissue is replaced with an ice-cold organ storage solution until the autograft pancreatic implant happens.

Pancreas transplant is a major surgery which may have serious complications. About 25% patients after pancreas transplant need to undergo second surgery for problems such as infection and bleeding. A common complication with this surgery is chances of rejection when the body’s immune system takes the donated pancreas as foreign body and attacks it. To prevent chances of rejection immunosuppressants need to be taken for a life time, which has its own risk increasing vulnerability to cancer and infection.

In recent years, the success rate for pancreas transplant has increased considerably and complications reduced. The chances of survival one year after the surgery are 95% with 80-85% chances of pancreas being functional. The procedure is strenuous for the person who undergoes it, typically have to stay in the hospital for 2-3 weeks. In most cases, patients can perform everyday functions normal few months after the surgery.

Multi-Specialty Jehangir Hospital is the best hospital in Pune providing health care services related to heart, kidney, joints, critical care and more.

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